Replacement purchase for a 500 MHz NMR console

The research groups at the BNMRZ employ NMR spectroscopy to obtain molecular and mechanistic insight for essential biological processes that underlie physiological and diseaselinked cellular processes. The application concerns a replacement console for a 500 MHz WB solid-state NMR spectrometer. Research topics involve the analysis of protein structure and dynamics of amyloid fibrils, membrane proteins and virus assemblies. An additional focus area is the development of methods for MAS solid-state NMR. The 500 MHz spectrometer is essential for this work, as MAS solid-state NMR experiments will be implemented and tested first at low field, before experiments involving biologically interesting samples will be performed at higher magnetic field strengths.

BNMRZ的研究组采用NMR光谱法获得了基本生理和疾病疾病细胞过程的基本生物学过程的分子和机械见解。该应用程序涉及500 MHz WB固态NMR光谱仪的替换控制台。研究主题涉及分析蛋白质结构和淀粉样蛋白原纤维，膜蛋白和病毒组件的动力学。另一个重点是开发MAS固态NMR的方法。 500 MHz光谱仪对于这项工作至关重要，因为在涉及较高磁场强度的实验之前，将首先在低场上实施和测试MAS固态NMR实验。