Discovery and validation of prenatal biomarkers for improved outcome prediction and prognostication of congenital diaphragmatic hernia

Children with congenital diaphragmatic hernia (CDH) and their families deserve optimal counselling with accurate outcome prediction and prognostication at the time of the prenatal diagnosis. Currently, established imaging techniques are insufficient to serve these demands. CDH specific and individual biomarkers obtained from maternal body fluids (e.g. plasma) would address this knowledge gap and add substantially to the current diagnostic work up. Circular RNAs (circRNAs) have the potential to meet these requirements. Therefore, the main objective of the proposed project will be to determine if circRNAs can be used as biomarkers for prenatal prognostication and severity assessment in CDH.

先天性隔膜疝（CDH）及其家人的儿童应在产前诊断时进行准确的结果预测和预测。当前，已建立的成像技术不足以满足这些需求。从母体体液（例如等离子体）获得的CDH特异性和个体生物标志物将解决此知识差距，并大大增加当前诊断工作。循环RNA（CIRCRNA）有可能满足这些要求。因此，拟议项目的主要目的是确定CIRCRNA是否可以用作CDH中产前预后和严重性评估的生物标志物。